Loading...
research article
Synthesis of branched seven-membered 1-N-iminosugars and their evaluation as glycosidase inhibitors
Four branched tetra- and pentahydroxylated azepanes have been synthesized from a common azepane precursor through dihydroxylation followed by deoxygenation. They have been assayed as glycosidase inhibitors on a panel of 22 glycosidases and one methylated azepane displayed selective, competitive, and moderate inhibition toward bovine kidney alpha-L-fucosidase. (C) 2011 Elsevier Ltd. All rights reserved.
Use this identifier to reference this record
Type
research article
Web of Science ID
WOS:000305338000011
Authors
Publication date
2012
Published in
Volume
356
Start page
110
End page
114
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
July 13, 2012