MicroRNA-124 Is a Subventricular Zone Neuronal Fate Determinant

New neurons are continuously generated from neural stem cells with astrocyte properties, which reside in close proximity to the ventricle in the postnatal and adult brain. In this study we found that microRNA-124 (miR-124) dictates postnatal neurogenesis in the mouse subventricular zone. Using a transgenic reporter mouse we show that miR-124 expression is initiated in the rapid amplifying progenitors and remains expressed in the resulting neurons. When we stably inhibited miR-124 in vivo, neurogenesis was blocked, leading to the appearance of ectopic cells with astrocyte characteristics in the olfactory bulb. Conversely, when we overexpressed miR-124, neural stem cells were not maintained in the subventricular zone and neurogenesis was lost. In summary, our results demonstrate that miR-124 is a neuronal fate determinant in the subventricular zone.


Published in:
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32, 26, 8879-89
Year:
2012
Publisher:
Society for Neuroscience
ISSN:
1529-2401
Laboratories:




 Record created 2012-06-28, last modified 2018-12-03

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