Oligonucleotide Delivery by Cell-Penetrating "Striped" Nanoparticles

Gold nanoparticles coated with homogeneous (MUS) or "striped" (MUS-OT) ligand shells can be conjugated with double or single stranded DNA, and particles with either ligand configuration effectively carry DNA into melanoma tumor cells. When endocytosis is inhibited, however, MUS-OT particles continue to mediate DNA delivery, while the delivery ability of MUS particles is abolished. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Published in:
Angewandte Chemie-International Edition, 50, 12312-12315
Year:
2011
Keywords:
Laboratories:




 Record created 2012-06-25, last modified 2018-03-17


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