Synthesis of Trifluoromethyl-Substituted Cyclopropanes via Sequential Kharasch–Dehalogenation Reactions

A two-step process for the synthesis of trifluoromethyl-substituted cyclopropanes is described. Halothane, an anesthetic agent, is added to olefins in a ruthenium-catalyzed Kharasch reaction. The resulting 1,3-dihalides are converted into cyclopropanes by dehalogenation with magnesium. This procedure represents an alternative to metal-catalyzed cyclopropanations involving trifluoromethyl diazomethane.


Published in:
Organic Letters, 14, 3060-3063
Year:
2012
Publisher:
American Chemical Society
ISSN:
1523-7060
Keywords:
Laboratories:


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 Record created 2012-06-21, last modified 2018-03-17

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