000178127 001__ 178127
000178127 005__ 20190316235414.0
000178127 0247_ $$2doi$$a10.2353/ajpath.2010.090786
000178127 022__ $$a1525-2191
000178127 037__ $$aARTICLE
000178127 245__ $$aElusive identities and overlapping phenotypes of proangiogenic myeloid cells in tumors
000178127 269__ $$a2010
000178127 260__ $$c2010
000178127 336__ $$aReviews
000178127 520__ $$aIt is now established that bone marrow-derived myeloid cells regulate tumor angiogenesis. This was originally inferred from studies of human tumor biopsies in which a positive correlation was seen between the number of tumor-infiltrating myeloid cells, such as macrophages and neutrophils, and tumor microvessel density. However, unequivocal evidence was only provided once mouse models were used to examine the effects on tumor angiogenesis by genetically or pharmacologically targeting myeloid cells. Since then, identifying the exact myeloid cell types involved in this process has proved challenging because of myeloid cell heterogeneity and the expression of overlapping phenotypic markers in tumors. As a result, investigators often simply refer to them now as "bone marrow-derived myeloid cells." Here we review the findings of various attempts to phenotype the myeloid cells involved and discuss the therapeutic implications of correctly identifying-and thus being able to target-this proangiogenic force in tumors.
000178127 6531_ $$aNeovascularization, Pathologic
000178127 700__ $$aCoffelt, Seth B.
000178127 700__ $$aLewis, Claire E.
000178127 700__ $$aNaldini, Luigi
000178127 700__ $$aBrown, J. Martin
000178127 700__ $$aFerrara, Napoleone
000178127 700__ $$0246289$$aDe Palma, Michele$$g213145
000178127 773__ $$j176$$k4$$q1564-76$$tThe American journal of pathology
000178127 8564_ $$s345546$$uhttps://infoscience.epfl.ch/record/178127/files/JPATH176001564.pdf$$yPublisher's version$$zPublisher's version
000178127 909C0 $$0252421$$pUPDEPALMA$$xU12442
000178127 909CO $$ooai:infoscience.tind.io:178127$$pSV$$preview$$qGLOBAL_SET
000178127 917Z8 $$x182396
000178127 937__ $$aEPFL-REVIEW-178127
000178127 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000178127 980__ $$aREVIEW