Phosphocreatine line with changes in localised 31P MRS of exercising muscle at 7T

The aim was to investigate changes in the line width of high-energy phosphates solely originating from the intramyocellular compartment by temporally resolved localised 31P-MRS after aerobic calf muscle exercise. Semi-Laser [2] localised 31P-MRS of gastrocnemius muscle and pulse-acquire-MRS (10cm-surface coil) were performed alternatingley in three exercise bouts separated by >20min inactivity. PCr and Pi were quantified in AMARES from single acquitsitions, with TR=6s. While Pi line width is known to change due to pH, to our knowledge this is the first observation of an exercise induced line width increase of intra-myocellular PCr, which may be associated with myoglobin deoxygenation.


Published in:
Electronic Suppl to Magn Reson Mater Phy, 24, Suppl 1, 642
Presented at:
28th Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology, Leipzig, Germany, October 6-8, 2011
Year:
2011
Keywords:
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 Record created 2012-05-29, last modified 2018-09-13

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