Direct in vivo measurement of human cerebral GABA concentration using MEGA-editing at 7 Tesla

Spectral editing of the GABA spin system is hampered by coediting of macromolecule (MM) coherences. To reduce contamination arising from MMs in spectra edited for GABA, the highest field strength currently available for human experimentation (7 Tesla) and MEGA-based editing were used. Despite judicious choice of experimental parameters, MM contamination was found to arise from field drifts. When the MM contribution was accounted for, [GABA] = 0.75 +/- 0.14 micromol/g (mean +/- SD, N = 16) relative to 8 micromol/g creatine (Cr), whereas without accounting for the MM signal [GABA*] = 0.88 +/- 0.23 micromol/g (mean +/- SD, N = 16). Incorporating the direct experimental assessment of MM contamination to the edited GABA signal substantially reduced the variance of the measurement, resulting in concentrations that were in excellent agreement with previous (13)C labeling experiments.


Published in:
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine, 47, 5, 1009-12
Year:
2002
Publisher:
Wiley-Blackwell
ISSN:
0740-3194
Keywords:
Laboratories:




 Record created 2012-05-27, last modified 2018-10-01

Publisher's version:
Download fulltext
PDF

Rate this document:

Rate this document:
1
2
3
 
(Not yet reviewed)