A localization method for the measurement of fast relaxing 13C NMR signals in humans at high magnetic fields
Nuclear magnetic resonance (NMR) signals with short T1 and T2, such as the 13C signal of glycogen, are difficult to localize in three dimensions without major signal loss. A pulse sequence that accomplishes the spatial localization of 1H-decoupled 13C NMR signals on a whole-body scanner within the Food and Drug Administration guidelines for specific absorption rates was designed. The method uses an optimized three-dimensional outer volume suppression scheme combined with one-dimensional image-selected in vivo spectroscopy and surface coil detection. The localization performance of the sequence was validated at 4 T with double chambered phantoms and 13C magnetic resonance imaging. Localized 13C spectra were acquired from human brain and muscle. © Springer-Verlag 2005.
Record created on 2012-05-26, modified on 2016-08-09