000177461 001__ 177461
000177461 005__ 20181203022727.0
000177461 0247_ $$2doi$$a10.1016/j.mri.2010.02.002
000177461 022__ $$a1873-5894
000177461 037__ $$aARTICLE
000177461 245__ $$aBOLD responses to trigeminal nerve stimulation
000177461 269__ $$a2010
000177461 260__ $$c2010
000177461 336__ $$aJournal Articles
000177461 520__ $$aThe current study investigates a new model of barrel cortex activation using stimulation of the infraorbital branch of the trigeminal nerve. A robust and reproducible activation of the rat barrel cortex was obtained following trigeminal nerve stimulation. Blood oxygen level-dependent (BOLD) effects were obtained in the primary somatosensory barrel cortex (S1BF), the secondary somatosensory cortex (S2) and the motor cortex. These cortical areas were reached from afferent pathways from the trigeminal ganglion, the trigeminal nuclei and thalamic nuclei from which neurons project their axons upon whisker stimulation. The maximum BOLD responses were obtained for a stimulus frequency of 1 Hz, a stimulus pulse width of 100 μs and for current intensities between 1.5 and 3 mA. The BOLD response was nonlinear as a function of frequency and current intensity. Additionally, modeling BOLD responses in the rat barrel cortex from separate cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO(2)) measurements showed good agreement with the shape and amplitude of measured BOLD responses as a function of stimulus frequency and will potentially allow to identify the sources of BOLD nonlinearities. Activation of the rat barrel cortex using trigeminal nerve stimulation will contribute to the interpretation of the BOLD signals from functional magnetic resonance imaging studies.
000177461 6531_ $$aCIBM-AIT
000177461 700__ $$0243727$$aJust, Nathalie$$g174562
000177461 700__ $$0243169$$aPetersen, Carl$$g157467
000177461 700__ $$0243712$$aGruetter, Rolf$$g161735
000177461 773__ $$j28$$k8$$q1143-51$$tMagnetic resonance imaging
000177461 8564_ $$s780192$$uhttps://infoscience.epfl.ch/record/177461/files/Just_TGN.pdf$$yPublisher's version$$zPublisher's version
000177461 909C0 $$0252477$$pCIBM$$xU12623
000177461 909C0 $$0252276$$pLIFMET$$xU10984
000177461 909C0 $$0252149$$pLSENS$$xU10837
000177461 909CO $$ooai:infoscience.tind.io:177461$$pSB$$pSV$$particle
000177461 917Z8 $$x161735
000177461 917Z8 $$x161735
000177461 917Z8 $$x161735
000177461 937__ $$aEPFL-ARTICLE-177461
000177461 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000177461 980__ $$aARTICLE