Dynamics of lactate concentration and blood oxygen level-dependent effect in the human visual cortex during repeated identical stimuli

In vivo 1H NMR spectroscopy at 7 T was utilized to measure the changes in lactate concentration upon repeated identical visual stimuli, each lasting for 2 min. The average amplitude of these increases was found to be reduced over time (P < 0.01), from 0.13 ± 0.02 μmol/g during the first half of the stimulation paradigm, to 0.06 ± 0.02 μmol/g during the second half of the stimulation paradigm. In contrast, the blood oxygen level-dependent (BOLD) effect on the fMRI water signal and on the height of the total creatine signal at 3.03 ppm was persistent during the whole observation period. This finding may suggest a differential adaptation of cortical output that is not reflected at the level of the global excitation-inhibition activity of the cortical canonical circuits. Alternative possibilities that could account for an adaptation of [Lac] changes are also discussed. © 2007 Wiley-Liss, Inc.


Published in:
Journal of Neuroscience Research, 85, 15, 3340-3346
Year:
2007
Publisher:
Wiley-Blackwell
ISSN:
0360-4012
Laboratories:




 Record created 2012-05-26, last modified 2018-03-17


Rate this document:

Rate this document:
1
2
3
 
(Not yet reviewed)