Delayed cortical impairment following lipopolysaccharide exposure in preterm fetal sheep

Preterm infants exhibit chronic deficits in white matter (WM) and cortical maturation. Although fetal infection/inflammation may contribute to WM pathology, the factors contributing to cortical changes are largely unknown. We examined the effect of fetal lipopolysaccharide (LPS) exposure on WM and cortical development as assessed by magnetic resonance imaging (MRI), electroencephalography (EEG), and histopathology in fetal sheep at preterm human equivalent age.


Published in:
Annals of neurology, 70, 5, 846-56
Year:
2011
ISSN:
1531-8249
Keywords:
Laboratories:




 Record created 2012-05-25, last modified 2018-03-18


Rate this document:

Rate this document:
1
2
3
 
(Not yet reviewed)