Gold nanoparticles functionalised with stable, fast water exchanging Gd3+ chelates as high relaxivity contrast agents for MRI

Gold nanoparticles functionalized with Gd3+ chelates displaying fast water exchange, superb pH stability and inertness towards transmetalation with Zn2+ have been prepared and characterized as a new high relaxivity (29 mM(-1) s(-1), 30 MHz, 25 degrees C) contrast agent potentially safe for in vivo MRI applications. The Lipari-Szabo treatment for internal rotation was used to evaluate the effect of linker flexibility on the relaxivity of the gold nanoparticles. The effect of fast water exchange on the relaxivity of gold nanoparticles functionalized with Gd3+ chelates is also addressed in this communication.


Published in:
Dalton Transactions, 41, 5472-5475
Year:
2012
Publisher:
Royal Society of Chemistry
ISSN:
1477-9226
Keywords:
Laboratories:


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 Record created 2012-05-04, last modified 2018-03-17

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