The RIP kinases: crucial integrators of cellular stress

Since the discovery of the first member ten years ago, the receptor-interacting protein (RIP) family kinases have emerged as essential sensors of cellular stress. The different members integrate both extracellular stress signals transmitted by various cell-surface receptors and signals emanating from intracellular stress. The cascades of events initiated by activated RIPs are complex. Not only are pro-survival, inflammatory and immune responses triggered by RIP kinases via the activation of transcription factors such as NF-kappaB and AP-1, but opposing, death-inducing programs can also be initiated by the RIP kinases. Hence, RIP kinases are crucial regulators of cell survival and cell death.


Published in:
Trends in biochemical sciences, 30, 3, 151-9
Year:
2005
Publisher:
Elsevier
ISSN:
0968-0004
Laboratories:


Note: The status of this file is: Involved Laboratories Only


 Record created 2012-04-26, last modified 2018-03-17

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