Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses

The early detection by the host of invading microorganisms, including viruses, depends on a limited number of specific receptors that recognize pathogen-associated molecular patterns (PAMPs). A few of these PAMPs, including ssRNA and dsRNA, are recognized by Toll-like receptors (TLR)-7/8 and TLR3, respectively. Activation of an antiviral TLR-dependent signaling cascade leads to the activation of the key transcription factors IRF and NF-kappaB, which promote antiviral responses through induction of specific genes. Recently, a second system has been described, which relies on the cytoplasmic recognition of dsRNA by RNA helicases such as RIG-I. In this review, we discuss the mechanistic aspects of these important arms of the host innate response to dsRNA and a few viral strategies utilized to counteract them.


Published in:
Molecular cell, 22, 5, 561-9
Year:
2006
Publisher:
Elsevier
ISSN:
1097-2765
Keywords:
Laboratories:




 Record created 2012-04-26, last modified 2018-01-28


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