Disruption of notch1 induces vascular remodeling, intussusceptive angiogenesis, and angiosarcomas in livers of mice
Dill, Michael T.; Rothweiler, Sonja; Djonov, Valentin; Hlushchuk, Ruslan; Tornillo, Luigi; Terracciano, Luigi; Meili-Butz, Silvia; Radtke, Freddy; Heim, Markus H.; Semela, David
2012
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Abstract

Notch signaling mediates embryonic vascular development and normal vascular remodeling; Notch1 knockout mice develop nodular regenerative hyperplasia (NRH). The pathogenesis of NRH is unclear, but has been associated with vascular injury in the liver sinusoids in clinical studies. We investigated the role of Notch1 signaling in liver sinusoidal endothelial cells (LSECs).

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Title Disruption of notch1 induces vascular remodeling, intussusceptive angiogenesis, and angiosarcomas in livers of mice
Author(s) Dill, Michael T. ; Rothweiler, Sonja ; Djonov, Valentin ; Hlushchuk, Ruslan ; Tornillo, Luigi ; Terracciano, Luigi ; Meili-Butz, Silvia ; Radtke, Freddy ; Heim, Markus H. ; Semela, David
Published in Gastroenterology
Volume 142
Issue 4
Pages 967-977.e2
Date 2012
ISSN 1528-0012
Keywords
DOI https://doi.org/10.1053/j.gastro.2011.12.052
Other identifier(s) View record in Web of Science
Laboratories UPRAD
Record Appears in Scientific production and competences > SV - School of Life Sciences > ISREC - Swiss Institute for Experimental Cancer Research > UPRAD - Prof. Radtke Group
Work produced at EPFL
Journal Articles
Published
Record creation date 2012-04-10