Disruption of notch1 induces vascular remodeling, intussusceptive angiogenesis, and angiosarcomas in livers of mice

Notch signaling mediates embryonic vascular development and normal vascular remodeling; Notch1 knockout mice develop nodular regenerative hyperplasia (NRH). The pathogenesis of NRH is unclear, but has been associated with vascular injury in the liver sinusoids in clinical studies. We investigated the role of Notch1 signaling in liver sinusoidal endothelial cells (LSECs).


Published in:
Gastroenterology, 142, 4, 967-977.e2
Year:
2012
ISSN:
1528-0012
Keywords:
Laboratories:


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 Record created 2012-04-10, last modified 2018-03-17

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