Disruption of notch1 induces vascular remodeling, intussusceptive angiogenesis, and angiosarcomas in livers of mice
Notch signaling mediates embryonic vascular development and normal vascular remodeling; Notch1 knockout mice develop nodular regenerative hyperplasia (NRH). The pathogenesis of NRH is unclear, but has been associated with vascular injury in the liver sinusoids in clinical studies. We investigated the role of Notch1 signaling in liver sinusoidal endothelial cells (LSECs).
Keywords: Vascular Tumor ; Liver Cancer ; Ephrin Signaling ; Sinusoidal Capillarization ; Nodular Regenerative Hyperplasia ; Endothelial-Cells ; Alagille-Syndrome ; Ephrin B2/Ephb4 ; Growth-Factor ; Rat-Liver ; Expression ; Pathway ; Model ; Inactivation
Record created on 2012-04-10, modified on 2016-08-09