000175937 001__ 175937
000175937 005__ 20181203022651.0
000175937 0247_ $$2doi$$a10.1021/nl103349s
000175937 02470 $$2ISI$$a000287049100034
000175937 037__ $$aARTICLE
000175937 245__ $$aNanotopographic Control of Neuronal Polarity
000175937 269__ $$a2011
000175937 260__ $$c2011
000175937 336__ $$aJournal Articles
000175937 520__ $$aWe employ simple geometrical rules to design a set of nanotopographies able to interfere with focal adhesion establishment during neuronal differentiation. Exploiting nanoimprint lithography techniques on cyclic-olefin-copolymer films, we demonstrate that by varying a single topographical parameter the orientation and maturation of focal adhesions can be finely modulated yielding independent control over the final number and the outgrowth direction of neurites. Taken together, this report provides a novel and promising approach to the rational design of biocompatible textured substrates for tissue engineering applications.
000175937 6531_ $$aCell polarity
000175937 6531_ $$aneuron
000175937 6531_ $$afocal adhesions
000175937 6531_ $$acontact guidance
000175937 6531_ $$atopography
000175937 6531_ $$aGrowth Cones
000175937 6531_ $$aFocal Adhesions
000175937 6531_ $$aCell-Adhesion
000175937 6531_ $$aDifferentiation
000175937 6531_ $$aTopography
000175937 6531_ $$aNanofibers
000175937 6531_ $$aNanoscale
000175937 6531_ $$aAlignment
000175937 6531_ $$aSurfaces
000175937 6531_ $$aLineage
000175937 700__ $$uNEST, CNR, Ist Nanosci, I-56126 Pisa, Italy$$aFerrari, Aldo
000175937 700__ $$uNEST, CNR, Ist Nanosci, I-56126 Pisa, Italy$$aCecchini, Marco
000175937 700__ $$uCornell Univ, Sch Elect & Comp Engn, Ithaca, NY 14853 USA$$aDhawan, Akshay
000175937 700__ $$0246201$$g218366$$uScuola Super Sant Anna, ARTS Lab, CH-8006 Zurich, Switzerland$$aMicera, Silvestro
000175937 700__ $$uNEST, CNR, Ist Nanosci, I-56126 Pisa, Italy$$aTonazzini, Ilaria
000175937 700__ $$uUniv Salento, NNL, Ist Nanosci, CNR,IIT Ctr Biomol Nanotechnol, I-73100 Lecce, Italy$$aStabile, Ripalta
000175937 700__ $$uUniv Salento, NNL, Ist Nanosci, CNR,IIT Ctr Biomol Nanotechnol, I-73100 Lecce, Italy$$aPisignano, Dario
000175937 700__ $$aBeltram, Fabio$$uNEST, CNR, Ist Nanosci, I-56126 Pisa, Italy
000175937 773__ $$j11$$tNano Letters$$q505-511
000175937 909C0 $$xU12522$$0252419$$pTNE
000175937 909C0 $$xU12599$$0252517$$pCNP
000175937 909CO $$pSTI$$particle$$ooai:infoscience.tind.io:175937
000175937 937__ $$aEPFL-ARTICLE-175937
000175937 973__ $$rREVIEWED$$sPUBLISHED$$aOTHER
000175937 980__ $$aARTICLE