000175936 001__ 175936
000175936 005__ 20181203022651.0
000175936 0247_ $$2doi$$a10.1007/s00221-011-2571-9
000175936 02470 $$2ISI$$a000288671400001
000175936 037__ $$aARTICLE
000175936 245__ $$aStump nerve signals during transcranial magnetic motor cortex stimulation recorded in an amputee via longitudinal intrafascicular electrodes
000175936 269__ $$a2011
000175936 260__ $$c2011
000175936 336__ $$aJournal Articles
000175936 520__ $$aDo central and peripheral motor pathways associated with an amputated limb retain at least some functions over periods of years? This problem could be addressed by evaluating the response patterns of nerve signals from peripheral motor fibers during transcranial magnetic stimulation (TMS) of corticospinal tracts. The aim of this study was to record for the first time TMS-related responses from the nerves of a left arm stump of an amputee via intrafascicular longitudinal flexible multi-electrodes (tfLIFE4) implanted for a prosthetic hand control. After tfLIFE4 implant in the stump median and ulnar nerves, TMS impulses of increasing intensity were delivered to the contralateral motor cortex while tfLIFE4 recordings were carried out. Combining TMS of increasing intensity and tfLIFE4 electrodes recordings, motor nerve activity possibly related to the missing limb motor control and selectively triggered by brain stimulation without significant electromyographic contamination was identified. These findings are entirely original and indicate that tfLIFE4 signals are clearly driven from M1 stimulation, therefore witnessing the presence in the stump nerves of viable motor signals from the CNS possibly useful for artificial prosthesis control.
000175936 6531_ $$aTranscranial magnetic stimulation
000175936 6531_ $$aIntrafascicular longitudinal flexible multi-electrodes
000175936 6531_ $$aPeripheral nerves signals
000175936 6531_ $$aElectrical-Stimulation
000175936 6531_ $$aSpinal-Cord
000175936 6531_ $$aBrain-Stimulation
000175936 6531_ $$aEvoked-Potentials
000175936 6531_ $$aHealthy Humans
000175936 6531_ $$aTarget Muscles
000175936 6531_ $$aAdult Monkeys
000175936 6531_ $$aHand Muscles
000175936 6531_ $$aIntact Man
000175936 6531_ $$aReorganization
000175936 700__ $$aRossini, P. M.$$uIRCCS S Raffaele Pisana, Rome, Italy
000175936 700__ $$0247771$$aRigosa, Jacopo$$g241251$$uScuola Super Sant Anna, Adv Robot Technol & Syst Lab, Pisa, Italy
000175936 700__ $$0246201$$aMicera, Silvestro$$g218366$$uScuola Super Sant Anna, Adv Robot Technol & Syst Lab, Pisa, Italy
000175936 700__ $$aAssenza, Giovanni$$uUniv Campus Biomed, Dept Neurol, I-00100 Rome, Italy
000175936 700__ $$aRossini, Luca$$uIRCCS S Raffaele Pisana, Rome, Italy
000175936 700__ $$aFerreri, Florinda$$uUniv Campus Biomed, Dept Neurol, I-00100 Rome, Italy
000175936 773__ $$j210$$q1-11$$tExperimental Brain Research
000175936 909C0 $$0252419$$pTNE$$xU12522
000175936 909C0 $$0252517$$pCNP$$xU12599
000175936 909CO $$ooai:infoscience.tind.io:175936$$pSTI$$particle
000175936 937__ $$aEPFL-ARTICLE-175936
000175936 973__ $$aOTHER$$rREVIEWED$$sPUBLISHED
000175936 980__ $$aARTICLE