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research article
Synthesis of a C-Iminoribofuranoside Analog of the Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitor FK866
FK866 (also named APO866 or WK175) is a potent NAMPT inhibitor being evaluated (Phase II) as a potential anticancer drug. The preparation of the C-iminoribofuranoside analog (2E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-{3-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]phenyl}prop-2-enamide ((-)-1) is reported.
Type
research article
Web of Science ID
WOS:000299160000003
Authors
Publication date
2012
Published in
Volume
95
Start page
34
End page
42
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
March 1, 2012
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