Synthesis of a C-Iminoribofuranoside Analog of the Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitor FK866
Gillig, Annabelle; Majjigapu, Somi Reddy; Sordat, Bernard; Vogel, Pierre
2012

Abstract

FK866 (also named APO866 or WK175) is a potent NAMPT inhibitor being evaluated (Phase II) as a potential anticancer drug. The preparation of the C-iminoribofuranoside analog (2E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-{3-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl]phenyl}prop-2-enamide ((-)-1) is reported.

Details

Title Synthesis of a C-Iminoribofuranoside Analog of the Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitor FK866
Author(s) Gillig, Annabelle ; Majjigapu, Somi Reddy ; Sordat, Bernard ; Vogel, Pierre
Published in Helvetica Chimica Acta
Volume 95
Pages 34-42
Date 2012
Keywords
DOI https://doi.org/10.1002/hlca.201100415
Other identifier(s) View record in Web of Science
Laboratories LGSA
Record Appears in Scientific production and competences > SB - School of Basic Sciences > SB Archives > LGSA - Laboratory of Glycochemistry and Asymmetric Synthesis
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date 2012-03-01

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