Like a Bolt from the Blue: Phthalocyanines in Biomedical Optics
The purpose of this review is to compile preclinical and clinical results on phthalocyanines (Pcs) as photosensitizers (PS) for Photodynamic Therapy (PDT) and contrast agents for fluorescence imaging. Indeed, Pcs are excellent candidates in these fields due to their strong absorbance in the NIR region and high chemical and photo-stability. In particular, this is mostly relevant for their in vivo activation in deeper tissular regions. However, most Pcs present two major limitations, i.e., a strong tendency to aggregate and a low water-solubility. In order to overcome these issues, both chemical tuning and pharmaceutical formulation combined with tumor targeting strategies were applied. These aspects will be developed in this review for the most extensively studied Pcs during the last 25 years, i.e., aluminium-, zinc- and silicon-based Pcs.
Keywords: biomedical optics ; fluorescence diagnosis ; phthalocyanines ; NIR dyes ; photodynamic therapy ; Vitro Photodynamic Activities ; Sulfonated Aluminum Phthalocyanines ; Water-Soluble Phthalocyanines ; Chinese-Hamster Cells ; Bovine Serum-Albumin ; Internalizing Monoclonal-Antibodies ; Hexadecafluoro Zinc Phthalocyanine ; Photosensitizing Anticancer Drugs ; Poly(Lactic Acid) Nanoparticles ; Responsive Polymeric Micelles
Record created on 2012-03-01, modified on 2016-08-09