000173971 001__ 173971
000173971 005__ 20180317092718.0
000173971 0247_ $$2doi$$a10.1016/j.nbd.2011.07.001
000173971 022__ $$a0969-9961
000173971 02470 $$2ISI$$a000297883500011
000173971 037__ $$aARTICLE
000173971 245__ $$aWhat have we learned from gene expression profiles in Huntington's disease?
000173971 260__ $$bElsevier$$c2012
000173971 269__ $$a2012
000173971 336__ $$aReviews
000173971 520__ $$aThe availability of many high-quality genome-wide expression datasets has provided an exciting and unique opportunity to better understand the molecular etiology of Huntington's disease. Combining this knowledge with other aspects of huntingtin biology and disease modification screens is yielding important new insights into disease-mitigating therapeutic strategies. Having followed this line of inquiry for some time, we note that there have been a number of surprises regarding the subsequently confirmed relationships between gene expression and disease etiology. Moreover, the complexity and sheer number of proposed mechanisms by which huntingtin can perturb gene expression continues to expand. Nonetheless, ongoing efforts to enthusiastically and critically evaluate the relationships between HD pathobiology and gene expression promise to deliver accurate predictions as to which therapeutic strategies will be most effective. An exciting new arm of this research also demonstrates the power of pharmacogenomics to detect (and rule out) important neuroprotective gene expression effects. (C) 2011 Elsevier Inc. All rights reserved.
000173971 6531_ $$aPolyglutamine disease
000173971 6531_ $$ahuntingtin
000173971 6531_ $$aTranscriptomic profiling
000173971 6531_ $$aStriatum
000173971 6531_ $$aCortex
000173971 6531_ $$aMuscle
000173971 6531_ $$aBlood
000173971 6531_ $$aMicroarray
000173971 6531_ $$aBiomarker
000173971 6531_ $$aHistone Deacetylase Inhibitors
000173971 6531_ $$aNeuronal Intranuclear Inclusions
000173971 6531_ $$aCre-Mediated Transcription
000173971 6531_ $$aAdenosine A(2A) Receptors
000173971 6531_ $$aTransgenic Mouse Models
000173971 6531_ $$aCell-Cell Interactions
000173971 6531_ $$aMutant-Huntingtin
000173971 6531_ $$aBinding-Protein
000173971 6531_ $$aExpanded Polyglutamine
000173971 6531_ $$aSynaptic Plasticity
000173971 700__ $$aSeredenina, Tamara
000173971 700__ $$0240509$$aLuthi-Carter, Ruth$$g158211
000173971 773__ $$j45$$q83-98$$tNeurobiology Of Disease
000173971 909CO $$ooai:infoscience.tind.io:173971$$preview
000173971 909C0 $$0252338$$pLNGF$$xU10838
000173971 917Z8 $$x175015
000173971 937__ $$aEPFL-REVIEW-173971
000173971 973__ $$aEPFL$$rNON-REVIEWED$$sPUBLISHED
000173971 980__ $$aREVIEW