The Pollutant Diethylhexyl Phthalate Regulates Hepatic Energy Metabolism via Species-Specific PPAR alpha-Dependent Mechanisms
BACKGROUND: The modulation of energetic homeostasis by pollutants has recently emerged as a potential contributor to the onset of metabolic disorders. Diethylhexyl phthalate (DEHP) is a widely used industrial plasticizer to which humans are widely exposed. Phthalates can activate the three peroxisome proliferator-activated receptor (PPAR) isotypes on cellular models and induce peroxisome proliferation in rodents.
Keywords: Dehp ; endocrine disruptor ; metabolism ; Ppar ; species specificity ; Activated-Receptor-Alpha ; Endocrine Disruptors ; Obesity Epidemic ; Hepatocellular Proliferation ; Waist Circumference ; Organotin Compounds ; Human Risk ; Gamma ; Liver ; Di(2-Ethylhexyl)Phthalate
Record created on 2011-12-16, modified on 2016-08-09