The Pollutant Diethylhexyl Phthalate Regulates Hepatic Energy Metabolism via Species-Specific PPAR alpha-Dependent Mechanisms
Feige, Jerome N.; Gerber, Alan; Casals-Casas, Cristina; Yang, Qian; Winkler, Carine; Bedu, Elodie; Bueno, Manuel; Gelman, Laurent; Auwerx, Johan; Gonzalez, Frank J.; Desvergne, Beatrice
2010

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Abstract

BACKGROUND: The modulation of energetic homeostasis by pollutants has recently emerged as a potential contributor to the onset of metabolic disorders. Diethylhexyl phthalate (DEHP) is a widely used industrial plasticizer to which humans are widely exposed. Phthalates can activate the three peroxisome proliferator-activated receptor (PPAR) isotypes on cellular models and induce peroxisome proliferation in rodents.

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Title The Pollutant Diethylhexyl Phthalate Regulates Hepatic Energy Metabolism via Species-Specific PPAR alpha-Dependent Mechanisms
Author(s) Feige, Jerome N. ; Gerber, Alan ; Casals-Casas, Cristina ; Yang, Qian ; Winkler, Carine ; Bedu, Elodie ; Bueno, Manuel ; Gelman, Laurent ; Auwerx, Johan ; Gonzalez, Frank J. ; Desvergne, Beatrice
Published in Environmental Health Perspectives
Volume 118
Pages 234-241
Date 2010
Keywords
DOI https://doi.org/10.1289/ehp.0901217
Other identifier(s) View record in Web of Science
Laboratories NCEM
Record Appears in Scientific production and competences > SV - School of Life Sciences > IBI-SV - Interfaculty Institute of Bioengineering > NCEM - Nestlé Chair in Energy Metabolism
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date 2011-12-16

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