Synthesis and glycosidase inhibitory activity of 1-amino-3,6-anhydro-1-deoxy-D-sorbitol derivatives

3,6-Anhydro-1-(aryl or alkylamino)-1-deoxy-D-sorbitol derivatives have been prepared in four steps from isosorbide, a by-product from the starch industry. The inhibitory activities of these new compounds have been evaluated towards 13 glycosidases. A first lead-compound was identified, which inhibited beta-N-acetylglucosaminidase from bovine kidney (82% inhibition at 1 mM). (C) 2009 Elsevier Inc. All rights reserved.


Published in:
Bioorganic Chemistry, 38, 43-47
Year:
2010
Keywords:
Laboratories:




 Record created 2011-12-16, last modified 2018-09-13


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