Water around thermophilic proteins: the role of charged and apolar atoms

The thermal response of three proteins with mesophilic, thermophilic and hyperthermophilic character hints at the essential role played in thermostability by the protein-water interface. The formation of spanning water clusters enveloping the macromolecule and their resistance to thermal stress is shown to correlate with the charge distribution at the protein surface; in particular our findings suggest an effective role of the superficial charge distribution in stabilizing the global connectivity of the hydration water.


Published in:
Journal Of Physics-Condensed Matter, 22, -
Presented at:
Workshop on Modeling and Simulation of Water at Interfaces from Ambient to Supercooled Conditions., Lausanne, SWITZERLAND, Jun 29-Jul 01, 2009
Year:
2010
Keywords:
Laboratories:




 Record created 2011-12-16, last modified 2018-03-17


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