Decaprenylphosphoryl-beta-D-Ribose 2 '-Epimerase from Mycobacterium tuberculosis is a Magic Drug Target
Tuberculosis is still a leading cause of death in developing countries and a resurgent disease in developed countries. The selection and soaring spread of Mycobacterium tuberculosis multidrug-resistant (MDR-TB) and extensively drug-resistant strains (XDR-TB) is a severe public health problem. Currently, there is an urgent need of new drugs for tuberculosis treatment, with novel mechanisms of action and, moreover, the necessity to identify new drug targets.
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Keywords: Mycobacterium tuberculosis ; Rv3790 (DprE1) ; cellular target ; cell wall ; new drugs ; Cell-Wall ; Resistant Tuberculosis ; Current Challenges ; Atp Synthase ; D-Arabinose ; Biosynthesis ; Strategies ; Genes ; Benzothiazinones ; Antibiotics
Record created on 2011-12-16, modified on 2016-08-09