000172455 001__ 172455
000172455 005__ 20181203022558.0
000172455 0247_ $$2doi$$a10.1038/nbt.1665
000172455 022__ $$a1087-0156
000172455 02470 $$2ISI$$a000280757500023
000172455 037__ $$aARTICLE
000172455 245__ $$aThe MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models
000172455 260__ $$bNature Publishing Group$$c2010
000172455 269__ $$a2010
000172455 336__ $$aJournal Articles
000172455 520__ $$aGene expression data from microarrays are being applied to predict preclinical and clinical endpoints, but the reliability of these predictions has not been established. In the MAQC-II project, 36 independent teams analyzed six microarray data sets to generate predictive models for classifying a sample with respect to one of 13 endpoints indicative of lung or liver toxicity in rodents, or of breast cancer, multiple myeloma or neuroblastoma in humans. In total, >30,000 models were built using many combinations of analytical methods. The teams generated predictive models without knowing the biological meaning of some of the endpoints and, to mimic clinical reality, tested the models on data that had not been used for training. We found that model performance depended largely on the endpoint and team proficiency and that different approaches generated models of similar performance. The conclusions and recommendations from MAQC-II should be useful for regulatory agencies, study committees and independent investigators that evaluate methods for global gene expression analysis.
000172455 6531_ $$aGene-Expression Data
000172455 6531_ $$aControl Maqc Project
000172455 6531_ $$aMultiple-Myeloma
000172455 6531_ $$aBreast-Cancer
000172455 6531_ $$aPublished Microarray
000172455 6531_ $$aFollicular Lymphoma
000172455 6531_ $$aRisk-Stratification
000172455 6531_ $$aDna Microarrays
000172455 6531_ $$aClassification
000172455 6531_ $$aPerformance
000172455 700__ $$aShi, Leming
000172455 700__ $$aCampbell, Gregory
000172455 700__ $$aJones, Wendell D.
000172455 700__ $$aCampagne, Fabien
000172455 700__ $$aWen, Zhining
000172455 700__ $$aWalker, Stephen J.
000172455 700__ $$aSu, Zhenqiang
000172455 700__ $$aChu, Tzu-Ming
000172455 700__ $$aGoodsaid, Federico M.
000172455 700__ $$aPusztai, Lajos
000172455 700__ $$aShaughnessy, John D.
000172455 700__ $$aOberthuer, Andre
000172455 700__ $$aThomas, Russell S.
000172455 700__ $$aPaules, Richard S.
000172455 700__ $$aFielden, Mark
000172455 700__ $$aBarlogie, Bart
000172455 700__ $$aChen, Weijie
000172455 700__ $$aDu, Pan
000172455 700__ $$aFischer, Matthias
000172455 700__ $$aFurlanello, Cesare
000172455 700__ $$aGallas, Brandon D.
000172455 700__ $$aGe, Xijin
000172455 700__ $$aMegherbi, Dalila B.
000172455 700__ $$aSymmans, W. Fraser
000172455 700__ $$aWang, May D.
000172455 700__ $$aZhang, John
000172455 700__ $$aBitter, Hans
000172455 700__ $$aBrors, Benedikt
000172455 700__ $$aBushel, Pierre R.
000172455 700__ $$aBylesjo, Max
000172455 700__ $$aChen, Minjun
000172455 700__ $$aCheng, Jie
000172455 700__ $$aCheng, Jing
000172455 700__ $$aChou, Jeff
000172455 700__ $$aDavison, Timothy S.
000172455 700__ $$aDelorenzi, Mauro
000172455 700__ $$aDeng, Youping
000172455 700__ $$aDevanarayan, Viswanath
000172455 700__ $$aDix, David J.
000172455 700__ $$aDopazo, Joaquin
000172455 700__ $$aDorff, Kevin C.
000172455 700__ $$aElloumi, Fathi
000172455 700__ $$aFan, Jianqing
000172455 700__ $$aFan, Shicai
000172455 700__ $$aFan, Xiaohui
000172455 700__ $$aFang, Hong
000172455 700__ $$aGonzaludo, Nina
000172455 700__ $$aHess, Kenneth R.
000172455 700__ $$aHong, Huixiao
000172455 700__ $$aHuan, Jun
000172455 700__ $$aIrizarry, Rafael A.
000172455 700__ $$aJudson, Richard
000172455 700__ $$aJuraeva, Dilafruz
000172455 700__ $$aLababidi, Samir
000172455 700__ $$aLambert, Christophe G.
000172455 700__ $$aLi, Li
000172455 700__ $$aLi, Yanen
000172455 700__ $$aLi, Zhen
000172455 700__ $$aLin, Simon M.
000172455 700__ $$aLiu, Guozhen
000172455 700__ $$aLobenhofer, Edward K.
000172455 700__ $$aLuo, Jun
000172455 700__ $$aLuo, Wen
000172455 700__ $$aMcCall, Matthew N.
000172455 700__ $$aNikolsky, Yuri
000172455 700__ $$aPennello, Gene A.
000172455 700__ $$aPerkins, Roger G.
000172455 700__ $$aPhilip, Reena
000172455 700__ $$aPopovici, Vlad
000172455 700__ $$aPrice, Nathan D.
000172455 700__ $$aQian, Feng
000172455 700__ $$aScherer, Andreas
000172455 700__ $$aShi, Tieliu
000172455 700__ $$aShi, Weiwei
000172455 700__ $$aSung, Jaeyun
000172455 700__ $$aThierry-Mieg, Danielle
000172455 700__ $$aThierry-Mieg, Jean
000172455 700__ $$aThodima, Venkata
000172455 700__ $$aTrygg, Johan
000172455 700__ $$aVishnuvajjala, Lakshmi
000172455 700__ $$aWang, Sue Jane
000172455 700__ $$aWu, Jianping
000172455 700__ $$aWu, Yichao
000172455 700__ $$aXie, Qian
000172455 700__ $$aYousef, Waleed A.
000172455 700__ $$aZhang, Liang
000172455 700__ $$aZhang, Xuegong
000172455 700__ $$aZhong, Sheng
000172455 700__ $$aZhou, Yiming
000172455 700__ $$aZhu, Sheng
000172455 700__ $$aArasappan, Dhivya
000172455 700__ $$aBao, Wenjun
000172455 700__ $$aLucas, Anne Bergstrom
000172455 700__ $$aBerthold, Frank
000172455 700__ $$aBrennan, Richard J.
000172455 700__ $$aBuness, Andreas
000172455 700__ $$aCatalano, Jennifer G.
000172455 700__ $$aChang, Chang
000172455 700__ $$aChen, Rong
000172455 700__ $$aCheng, Yiyu
000172455 700__ $$aCui, Jian
000172455 700__ $$aCzika, Wendy
000172455 700__ $$aDemichelis, Francesca
000172455 700__ $$aDeng, Xutao
000172455 700__ $$aDosymbekov, Damir
000172455 700__ $$aEils, Roland
000172455 700__ $$aFeng, Yang
000172455 700__ $$aFostel, Jennifer
000172455 700__ $$aFulmer-Smentek, Stephanie
000172455 700__ $$aFuscoe, James C.
000172455 700__ $$aGatto, Laurent
000172455 700__ $$aGe, Weigong
000172455 700__ $$0243936$$g151741$$aGoldstein, Darlene R.
000172455 700__ $$aGuo, Li
000172455 700__ $$aHalbert, Donald N.
000172455 700__ $$aHan, Jing
000172455 700__ $$aHarris, Stephen C.
000172455 700__ $$aHatzis, Christos
000172455 700__ $$aHerman, Damir
000172455 700__ $$aHuang, Jianping
000172455 700__ $$aJensen, Roderick V.
000172455 700__ $$aJiang, Rui
000172455 700__ $$aJohnson, Charles D.
000172455 700__ $$aJurman, Giuseppe
000172455 700__ $$aKahlert, Yvonne
000172455 700__ $$aKhuder, Sadik A.
000172455 700__ $$aKohl, Matthias
000172455 700__ $$aLi, Jianying
000172455 700__ $$aLi, Li
000172455 700__ $$aLi, Menglong
000172455 700__ $$aLi, Quan-Zhen
000172455 700__ $$aLi, Shao
000172455 700__ $$aLi, Zhiguang
000172455 700__ $$aLiu, Jie
000172455 700__ $$aLiu, Ying
000172455 700__ $$aLiu, Zhichao
000172455 700__ $$aMeng, Lu
000172455 700__ $$aMadera, Manuel
000172455 700__ $$aMartinez-Murillo, Francisco
000172455 700__ $$aMedina, Ignacio
000172455 700__ $$aMeehan, Joseph
000172455 700__ $$aMiclaus, Kelci
000172455 700__ $$aMoffitt, Richard A.
000172455 700__ $$aMontaner, David
000172455 700__ $$aMukherjee, Piali
000172455 700__ $$aMulligan, George J.
000172455 700__ $$aNeville, Padraic
000172455 700__ $$aNikolskaya, Tatiana
000172455 700__ $$aNing, Baitang
000172455 700__ $$aPage, Grier P.
000172455 700__ $$aParker, Joel
000172455 700__ $$aParry, R. Mitchell
000172455 700__ $$aPeng, Xuejun
000172455 700__ $$aPeterson, Ron L.
000172455 700__ $$aPhan, John H.
000172455 700__ $$aQuanz, Brian
000172455 700__ $$aRen, Yi
000172455 700__ $$aRiccadonna, Samantha
000172455 700__ $$aRoter, Alan H.
000172455 700__ $$aSamuelson, Frank W.
000172455 700__ $$aSchumacher, Martin M.
000172455 700__ $$aShambaugh, Joseph D.
000172455 700__ $$aShi, Qiang
000172455 700__ $$aShippy, Richard
000172455 700__ $$aSi, Shengzhu
000172455 700__ $$aSmalter, Aaron
000172455 700__ $$aSotiriou, Christos
000172455 700__ $$aSoukup, Mat
000172455 700__ $$aStaedtler, Frank
000172455 700__ $$aSteiner, Guido
000172455 700__ $$aStokes, Todd H.
000172455 700__ $$aSun, Qinglan
000172455 700__ $$aTan, Pei-Yi
000172455 700__ $$aTang, Rong
000172455 700__ $$aTezak, Zivana
000172455 700__ $$aThorn, Brett
000172455 700__ $$aTsyganova, Marina
000172455 700__ $$aTurpaz, Yaron
000172455 700__ $$aVega, Silvia C.
000172455 700__ $$aVisintainer, Roberto
000172455 700__ $$avon Frese, Juergen
000172455 700__ $$aWang, Charles
000172455 700__ $$aWang, Eric
000172455 700__ $$aWang, Junwei
000172455 700__ $$aWang, Wei
000172455 700__ $$aWestermann, Frank
000172455 700__ $$aWilley, James C.
000172455 700__ $$aWoods, Matthew
000172455 700__ $$aWu, Shujian
000172455 700__ $$aXiao, Nianqing
000172455 700__ $$aXu, Joshua
000172455 700__ $$aXu, Lei
000172455 700__ $$aYang, Lun
000172455 700__ $$aZeng, Xiao
000172455 700__ $$aZhang, Jialu
000172455 700__ $$aZhang, Li
000172455 700__ $$aZhang, Min
000172455 700__ $$aZhao, Chen
000172455 700__ $$aPuri, Raj K.
000172455 700__ $$aScherf, Uwe
000172455 700__ $$aTong, Weida
000172455 700__ $$aWolfinger, Russell D.
000172455 773__ $$j28$$tNature Biotechnology$$q827-U109
000172455 909C0 $$xU10124$$0252136$$pSTAT
000172455 909CO $$pSB$$particle$$ooai:infoscience.tind.io:172455
000172455 917Z8 $$x111184
000172455 917Z8 $$x102085
000172455 937__ $$aEPFL-ARTICLE-172455
000172455 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000172455 980__ $$aARTICLE