Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer model

α-Synuclein aggregates in Lewy bodies and plays a central role in the pathogenesis of a group of neurodegenerative disorders, known as "Synucleinopathies", including Parkinson's disease. Parkin mutations result in loss of parkin E3-ubiquitin ligase activity and cause autosomal recessive early onset parkinsonism.


Published in:
Molecular neurodegeneration, 5, 47
Year:
2010
ISSN:
1750-1326
Laboratories:




 Record created 2011-12-16, last modified 2018-03-17

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