Benziodoxole-based hypervalent iodine reagents for atom-transfer reactions
In the last decades, hypervalent iodine reagents have raised from chemical curiosities to mainstream reagents in organic synthesis. The use of benziodoxole-derived reagents has been especially successful in oxidation methods, whereas non-cyclic iodinanes have been used both for oxidation and atom-transfer reactions. On the other hand, the exceptional properties of benziodoxole reagents for atom-transfer reactions have only started to attract the attention of the synthetic community more recently. In this review, progress in the use of these compounds for C-X and C-C bond formations will be presented. In particular, recent breakthroughs in trifluoromethylation and alkynylation reactions have been realized since 2006 based on benziodoxole-derived reagents and these results are the main focus of this article.
Keywords: Hydroxylative Phenol Dearomatization ; Mild Electrophilic Trifluoromethylation ; Catalyzed Direct Alkynylation ; Iodoxybenzoic Acid Ibx ; Organic-Synthesis ; Polyvalent Iodine ; Synthetic Utility ; Oxidative Dearomatization ; Tert-Butylperoxyiodanes ; C-H functionalization ; benziodoxole ; benziodoxolone ; Ethynyl benziodoxolone EBX
Record created on 2011-12-16, modified on 2016-08-09