000171659 001__ 171659
000171659 005__ 20181203022537.0
000171659 0247_ $$2doi$$a10.1016/j.jorganchem.2010.11.025
000171659 02470 $$2ISI$$a000287965700017
000171659 037__ $$aARTICLE
000171659 245__ $$aRuthenium(II) arene complexes with oligocationic triarylphosphine ligands: Synthesis, DNA interactions and in vitro properties
000171659 269__ $$a2011
000171659 260__ $$c2011
000171659 336__ $$aJournal Articles
000171659 520__ $$aThe synthesis, DNA binding properties and cytotoxicity of a series of Ru(II)-arene complexes containing oligocationic ammonium-functionalized triarylphosphines, of the type Ru(p-cymene)Cl-2(L) (L - oligocationic phosphine), are reported. The complexes are highly charged (the overall charge states being +3 and +6) and circular dichroism spectroscopy and gel electrophoresis studies indicate that the compounds interact strongly with DNA via electrostatic interactions. Despite forming strong interactions with DNA, the complexes exhibit only modest cytotoxicities on the human ovarian cancer cell lines A2780 and A2780cisR. (C) 2010 Elsevier B.V. All rights reserved.
000171659 6531_ $$aBioorganometallic chemistry
000171659 6531_ $$aRuthenium
000171659 6531_ $$aPhosphine ligands
000171659 6531_ $$aMetal-based drugs
000171659 6531_ $$aDNA binding
000171659 6531_ $$aHexacationic Dendriphos Ligands
000171659 6531_ $$aCross-Coupling Reaction
000171659 6531_ $$aCompound Rapta-C
000171659 6531_ $$aAnticancer Activity
000171659 6531_ $$aOrganometallic Ruthenium(Ii)
000171659 6531_ $$aDeoxyribonucleic-Acid
000171659 6531_ $$aCircular-Dichroism
000171659 6531_ $$aCatalytic-Activity
000171659 6531_ $$aPta Complexes
000171659 6531_ $$aBinding
000171659 700__ $$0242069$$g193365$$aSnelders, Dennis J. M.
000171659 700__ $$0242064$$g185115$$aCasini, Angela
000171659 700__ $$0244412$$g196585$$aEdafe, Fabio
000171659 700__ $$avan Koten, Gerard
000171659 700__ $$aGebbink, Robertus J. M. Klein
000171659 700__ $$aDyson, Paul J.$$g149418$$0240015
000171659 773__ $$j696$$tJournal Of Organometallic Chemistry$$q1108-1116
000171659 909C0 $$xU9$$0252010$$pLCOM
000171659 909CO $$pSB$$particle$$ooai:infoscience.tind.io:171659
000171659 917Z8 $$x135992
000171659 937__ $$aEPFL-ARTICLE-171659
000171659 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000171659 980__ $$aARTICLE