Preparation of 5-Membered Rings via Radical Addition-Translocation-Cyclization (RATC) Processes Mediated by Diethyl Thiophosphites
A practical method for the formation of thiophosphonates bearing functionalized monocyclic, fused bicyclic and spirocyclic residues is presented. The procedure requires the easily available terminal alkynes as starting materials as well as commercially and readily available reagents such as diethyl thiophosphite. The experimental procedure consists of a one-pot process without any slow addition of one of the reagents.
Keywords: alkynes ; dialkyl phosphites ; dialkyl thiophosphites ; 1,5-hydrogen transfer ; radical initiators ; radical reactions ; Phosphorus-Centered Radicals ; Hydrogen-Atom Abstraction ; Emmons-Type Reactions ; Tin-Free Procedure ; Cyclopentane Derivatives ; Homolytic Substitution ; 1,5-Hydrogen Transfer ; Dialkyl Phosphites ; Vinyl Radicals ; Dienes
Record created on 2011-12-16, modified on 2016-08-09