000171179 001__ 171179
000171179 005__ 20190316235239.0
000171179 0247_ $$2doi$$a10.1111/j.1462-5822.2011.01600.x
000171179 022__ $$a1462-5814
000171179 02470 $$2ISI$$a000292844500009
000171179 037__ $$aARTICLE
000171179 245__ $$aPore-forming toxins induce multiple cellular responses promoting survival
000171179 269__ $$a2011
000171179 260__ $$bWiley-Blackwell$$c2011
000171179 336__ $$aJournal Articles
000171179 520__ $$aPore-forming toxins (PFTs) are secreted proteins that contribute to the virulence of a great variety of bacterial pathogens. They inflict one of the more disastrous damages a target cell can be exposed to: disruption of plasma membrane integrity. Since this is an ancient form of attack, which bares similarities to mechanical membrane damage, cells have evolved response pathways to these perturbations. Here, it is reported that PFTs trigger very diverse yet specific response pathways. Many are triggered by the decrease in cytoplasmic potassium, which thus emerges as a central regulator. Upon plasma membrane damage, cells activate signalling pathways aimed at restoring plasma membrane integrity and ion homeostasis. Interestingly these pathways do not require protein synthesis. Cells also trigger signalling cascades that allow them to enter a quiescent-like state, where minimal energy is consumed while waiting for plasma membrane damage to be repaired. More specifically, protein synthesis is arrested, cytosolic constituents are recycled by autophagy and energy is stored in lipid droplets.
000171179 6531_ $$aActivated Protein-Kinase
000171179 6531_ $$aCholesterol-Dependent Cytolysin
000171179 6531_ $$aStaphylococcus-Aureus
000171179 6531_ $$aAlpha-Toxin
000171179 6531_ $$aSaccharomyces-Cerevisiae
000171179 6531_ $$aPlasma-Membrane
000171179 6531_ $$aEndoplasmic-Reticulum
000171179 6531_ $$aBacterial Toxins
000171179 6531_ $$aListeriolysin-O
000171179 6531_ $$aStreptolysin-O
000171179 700__ $$0240084$$g172745$$aGonzalez, Manuel R.
000171179 700__ $$0240087$$g169799$$aBischofberger, Mirko
000171179 700__ $$aFreche, Barbara
000171179 700__ $$aHo, Sylvia
000171179 700__ $$aParton, Robert G.
000171179 700__ $$avan der Goot, Gisou$$g171549$$0240085
000171179 773__ $$j13$$tCellular Microbiology$$k7$$q1026-1043
000171179 8564_ $$uhttps://infoscience.epfl.ch/record/171179/files/j.1462-5822.2011.01600.x_1.pdf$$zPublisher's version$$s1278540$$yPublisher's version
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000171179 917Z8 $$x171549
000171179 917Z8 $$x180272
000171179 917Z8 $$x182396
000171179 937__ $$aEPFL-ARTICLE-171179
000171179 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000171179 980__ $$aARTICLE