Decreased Striatal RGS2 Expression Is Neuroprotective in Huntington's Disease (HD) and Exemplifies a Compensatory Aspect of HD-Induced Gene Regulation
2011
Abstract
Background: The molecular phenotype of Huntington's disease (HD) is known to comprise highly reproducible changes in gene expression involving striatal signaling genes. Here we test whether individual changes in striatal gene expression are capable of mitigating HD-related neurotoxicity.
Details
Title
Decreased Striatal RGS2 Expression Is Neuroprotective in Huntington's Disease (HD) and Exemplifies a Compensatory Aspect of HD-Induced Gene Regulation
Author(s)
Seredenina, Tamara ; Gokce, Ozgun ; Luthi-Carter, Ruth
Published in
Plos One
Volume
6
Issue
7
Pages
e22231
Date
2011
Publisher
Public Library of Science
ISSN
1932-6203
Keywords
Other identifier(s)
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Laboratories
LNGF
Record Appears in
Scientific production and competences > SV - School of Life Sciences > SV Archives > LNGF - Functional Neurogenomics Laboratory
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date
2011-12-16