Altered Expression of the Transcription Factor Mef2c during Retinal Degeneration in Rpe65(-/-) Mice
PURPOSE. To investigate the role of the myocyte enhancer factor 2 (Mef2) transcription factor family in retinal diseases, Mef2c expression was assessed during retinal degeneration in the Rpe65(-/-) mouse model of Leber's congenital amaurosis (LCA). Mef2c-dependent expression of photoreceptor-specific genes was further addressed.
Keywords: Leber Congenital Amaurosis ; Skeletal-Muscle Development ; Severe Mental-Retardation ; Nuclear Receptor Nr2E3 ; Gene-Expression ; Visual Cycle ; In-Vivo ; Transgenic Mice ; Subunit Gene ; Mouse Model
Record created on 2011-12-16, modified on 2016-08-09