Efficient Synthesis of beta-Chlorovinylketones from Acetylene in Chloroaluminate Ionic Liquids

A method for the Friedel-Crafts-type insertion reaction of acetylene with acid chlorides in chloroaluminate ionic liquids is presented. The use of Ionic liquids not only serves to avoid the use of carbon tetrachloride or 1,2-dichloroethane but also suppresses side reactions, notably the polymerization of acetylene, which occurs in these chlorinated solvents. Consequently, the products can be isolated using a simpler purification procedure, giving a range of aromatic and aliphatic beta-chlorovinyl ketones In high yield and purity.


Published in:
Organic Letters, 13, 4048-4051
Year:
2011
Keywords:
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 Record created 2011-12-16, last modified 2018-03-17


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