000170919 001__ 170919
000170919 005__ 20181203022522.0
000170919 0247_ $$2doi$$a10.1523/JNEUROSCI.2360-11.2011
000170919 022__ $$a0270-6474
000170919 02470 $$2ISI$$a000295083300003
000170919 037__ $$aARTICLE
000170919 245__ $$aComplementary Function and Integrated Wiring of the Evolutionarily Distinct Drosophila Olfactory Subsystems
000170919 260__ $$bSociety for Neuroscience$$c2011
000170919 269__ $$a2011
000170919 336__ $$aJournal Articles
000170919 520__ $$aTo sense myriad environmental odors, animals have evolved multiple, large families of divergent olfactory receptors. How and why distinct receptor repertoires and their associated circuits are functionally and anatomically integrated is essentially unknown. We have addressed these questions through comprehensive comparative analysis of the Drosophila olfactory subsystems that express the ionotropic receptors (IRs) and odorant receptors (ORs). We identify ligands for most IR neuron classes, revealing their specificity for select amines and acids, which complements the broader tuning of ORs for esters and alcohols. IR and OR sensory neurons exhibit glomerular convergence in segregated, although interconnected, zones of the primary olfactory center, but these circuits are extensively interdigitated in higher brain regions. Consistently, behavioral responses to odors arise from an interplay between IR- and OR-dependent pathways. We integrate knowledge on the different phylogenetic and developmental properties of these receptors and circuits to propose models for the functional contributions and evolution of these distinct olfactory subsystems.
000170919 6531_ $$aIonotropic Glutamate Receptors
000170919 6531_ $$aMosquito Anopheles-Gambiae
000170919 6531_ $$aProtein-Coupled Receptors
000170919 6531_ $$aMale Courtship Behavior
000170919 6531_ $$aAntennal Lobe
000170919 6531_ $$aChemosensory Receptors
000170919 6531_ $$aLocal Interneurons
000170919 6531_ $$aMalaria Mosquito
000170919 6531_ $$aIn-Vivo
000170919 6531_ $$aOdorant Receptors
000170919 6531_ $$aEvolutionary Robotics
000170919 700__ $$aSilbering, Ana F.
000170919 700__ $$aRytz, Raphael
000170919 700__ $$aGrosjean, Yael
000170919 700__ $$aAbuin, Liliane
000170919 700__ $$0245307$$aRamdya, Pavan$$g196838
000170919 700__ $$aJefferis, Gregory S. X. E.
000170919 700__ $$aBenton, Richard
000170919 773__ $$j31$$q13357-13375$$tJournal Of Neuroscience
000170919 909C0 $$0252161$$pLIS$$xU10370
000170919 909CO $$ooai:infoscience.tind.io:170919$$pSTI$$particle
000170919 917Z8 $$x111729
000170919 917Z8 $$x255330
000170919 937__ $$aEPFL-ARTICLE-170919
000170919 973__ $$aEPFL$$rREVIEWED$$sPUBLISHED
000170919 980__ $$aARTICLE