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research article
Searching for the Protein Targets of Bioactive Molecules
2011
The identification of all protein targets of a given drug or bioactive molecule within the human body is a prerequisite for an understanding of its beneficial and deleterious activities. Current approaches to reveal protein targets often fail to reveal physiologically relevant interactions. Here we review a recently introduced yeast-based approach for the identification of the binding partners of small molecules. We discuss the advantages and limitations of the approach using the clinically approved drug sulfasalazine as an example.
Type
research article
Web of Science ID
WOS:000295811300021
Authors
Publication date
2011
Published in
Volume
65
Issue
9
Start page
720
End page
724
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
December 16, 2011
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