We perform a fit to the recent XENON 100 data and study its implications for Dark Matter scenarios. We find that Inelastic Dark Matter is disfavored as an explanation to the DAMA/LIBRA annual modulation signal. Concerning the scalar singlet DM model, we find that the XENON 100 data disfavors its constrained limit. We study the CMSSM as well as the low scale phenomenological MSSM taking into account latest Tevatron and LHC data (1.1/fb) about sparticles and B-s -> mu mu. After the EPS 2011 conference, LHC excludes the "Higgs-resonance" region of DM freeze-out and XENON 100 disfavors the "well-tempered" bino/higgsino, realized in the "focus-point" region of the CMSSM parameter space. The preferred region shifts to heavier sparticles, higher fine-tuning, higher tan beta and the quality of the fit deteriorates. (C) 2011 Elsevier B.V. All rights reserved.