Investigation of Protein Aggregation with a Bloch Surface Wave Sensor

We present a study of the dynamics of protein aggregation using a common path heterodyne Bloch surface wave label-free sensing scheme. We demonstrate the ability to detect, during thermal incubation, the first early dynamics events of protein aggregation and fibrillogenesis of amyloid- beta peptides, linked to Alzheimer’s Disease. The calibration of the biosensor is made using Lysozyme protein, a well establish protein model system to examine structural and mechanistic principles. The sensor is able to detect the formation of small soluble aggregates at early stages of oligomerisation.


Presented at:
BioPhotonics 2011 International Workshop, Parma, Italy, June 8-10, 2011
Year:
2011
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 Record created 2011-11-24, last modified 2018-01-28

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