ESAT-6 secretion-independent impact of ESX-1 genes espF and espG1 on virulence of Mycobacterium tuberculosis
Bottai, Daria; Majlessi, Laleh; Simeone, Roxane; Frigui, Wafa; Laurent, Christine; Lenormand, Pascal; Chen, Jeffrey; Rosenkrands, Ida; Huerre, Michel; Leclerc, Claude; Cole, Stewart T.; Brosch, Roland
2011

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Abstract

The pathogenesis of Mycobacterium tuberculosis largely depends on the secretion of the 6-kD early secreted antigenic target ESAT-6 (EsxA) and the 10-kD culture filtrate protein CFP-10 (EsxB) via the ESX-1/typeVII secretion system. Although gene products from the core RD1 region have been shown to be deeply implicated in this process, less is known about proteins encoded further upstream in the 5' region of the ESX-1 cluster, such as the ESX-1 secretion-associated proteins (Esps) EspF or EspG(1).

Details

Title ESAT-6 secretion-independent impact of ESX-1 genes espF and espG1 on virulence of Mycobacterium tuberculosis
Author(s) Bottai, Daria ; Majlessi, Laleh ; Simeone, Roxane ; Frigui, Wafa ; Laurent, Christine ; Lenormand, Pascal ; Chen, Jeffrey ; Rosenkrands, Ida ; Huerre, Michel ; Leclerc, Claude ; Cole, Stewart T. ; Brosch, Roland
Published in The Journal of infectious diseases
Volume 203
Issue 8
Pages 1155-64
Date 2011
Publisher Oxford University Press
ISSN 1537-6613
Keywords
Note National Licences
DOI https://doi.org/10.1093/infdis/jiq089
Other identifier(s) View record in Web of Science
Laboratories UPCOL
Record Appears in Scientific production and competences > SV - School of Life Sciences > SV Archives > UPCOL - Prof. Cole Group
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date 2011-11-24

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