Interference between PARPs and SIRT1: a novel approach to healthy ageing?
Poly(ADP-ribosyl) polymerases (PARPs) have traditionally been linked to chromosome maintenance and DNA repair. Recent findings identify PARPs as key modulators of metabolism through their influence on SIRT1 activity, hinting to a possible role of PARPs as longevity regulators.
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Keywords: aging ; metabolism ; longevity ; sirtuins ; Parp ; Poly(Adp-Ribose) Polymerase-Activity ; Dna-Damage ; Life-Span ; Nicotinamide ; Mice ; Metabolism ; Mouse ; Inhibition ; Activation ; Stability
Record created on 2011-11-15, modified on 2016-08-09