Interference between PARPs and SIRT1: a novel approach to healthy ageing?

Poly(ADP-ribosyl) polymerases (PARPs) have traditionally been linked to chromosome maintenance and DNA repair. Recent findings identify PARPs as key modulators of metabolism through their influence on SIRT1 activity, hinting to a possible role of PARPs as longevity regulators.


Published in:
Aging, 3, 5, 543-7
Year:
2011
ISSN:
1945-4589
Keywords:
Laboratories:




 Record created 2011-11-15, last modified 2018-03-17


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