000170203 001__ 170203
000170203 005__ 20181203022500.0
000170203 022__ $$a1545-2948
000170203 02470 $$2ISI$$a000299299600008
000170203 0247_ $$2doi$$a10.1146/annurev-genet-102209-163429
000170203 037__ $$aARTICLE
000170203 041__ $$aeng
000170203 245__ $$aA genetic approach to the transcriptional regulation of hox gene clusters
000170203 269__ $$a2011
000170203 260__ $$c2011
000170203 336__ $$aJournal Articles
000170203 490__ $$aAnnual Review of Genetics
000170203 520__ $$aThe evolution of vertebrate genomes was accompanied by an astounding increase in the complexity of their regulatory modalities. Genetic redundancy resulting from large-scale genome duplications at the base of the chordate tree was repeatedly exploited by the functional redeployment of paralogous genes via innovations in their regulatory circuits. As a paradigm of such regulatory evolution, we have extensively studied those control mechanisms at work in-cis over vertebrate Hox gene clusters. Here, we review the portfolio of genetic strategies that have been developed to tackle the intricate relationship between genomic topography and the transcriptional activities in this gene family, and we describe some of the mechanistic insights we gained by using the HoxD cluster as an example. We discuss the high heuristic value of this system in our general understanding of how changes in transcriptional regulation can diversify gene function and thereby fuel morphological evolution.
000170203 6531_ $$aembryonic patterning
000170203 6531_ $$acollinearity
000170203 6531_ $$amouse genetics
000170203 6531_ $$alocus topography
000170203 6531_ $$aregulatory evolution
000170203 6531_ $$aneofunctionalization
000170203 6531_ $$aGlobal Control Region
000170203 6531_ $$aEmbryonic Stem-Cells
000170203 6531_ $$aHuman Genome
000170203 6531_ $$aIn-Vivo
000170203 6531_ $$aExpression Domains
000170203 6531_ $$aUltraconserved Elements
000170203 6531_ $$aNuclear Reorganization
000170203 6531_ $$aPositional Information
000170203 6531_ $$aVertebrate Development
000170203 6531_ $$aConserved Sequences
000170203 700__ $$aTschopp, Patrick
000170203 700__ $$g141236$$aDuboule, Denis$$0240276
000170203 773__ $$j45$$tAnnual review of genetics$$q145-66
000170203 909C0 $$xU11705$$0252099$$pUPDUB
000170203 909CO $$pSV$$particle$$ooai:infoscience.tind.io:170203
000170203 917Z8 $$x182482
000170203 937__ $$aEPFL-ARTICLE-170203
000170203 973__ $$rNON-REVIEWED$$sPUBLISHED$$aEPFL
000170203 980__ $$aARTICLE