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000169588 022__ $$a1529-2401
000169588 0247_ $$2doi$$a10.1523/JNEUROSCI.2987-11.2011
000169588 037__ $$aARTICLE
000169588 245__ $$aGlobal Functional Connectivity Deficits in Schizophrenia Depend on Behavioral State
000169588 269__ $$a2011
000169588 260__ $$c2011
000169588 336__ $$aJournal Articles
000169588 520__ $$aSchizophrenia is a devastating psychiatric illness characterized by deterioration of cognitive and emotional processing. It has been hypothesized that aberrant cortical connectivity is implicated in the disease (Friston, 1998), yet previous studies of functional connectivity (FC) in schizophrenia have shown mixed results (Garrity et al., 2007; Jafri et al., 2008; Lynall et al., 2010). We measured FC using fMRI in human schizophrenia patients and healthy controls during two different tasks and a rest condition, and constructed a voxel-based global FC index. We found a striking FC decrease in patients compared with controls. In the task conditions, relatively weaker FC was specific to regions of cortex not active during the task. In the rest condition, the FC difference between patients and controls was larger and allowed a case-by-case separation between individuals of the two groups. The results suggest that the relative reduction of FC in schizophrenia is dependent on the state of cortical activity, with voxels not activated by the task showing higher levels of FC deficiency. This novel finding may shed light on previous reports of FC in schizophrenia. Whether this neural characteristic is related to the development of the disorder remains to be established.
000169588 6531_ $$aSchizophrenia
000169588 6531_ $$aFunctional connectivity
000169588 6531_ $$aResting state fMRI
000169588 6531_ $$afMRI
000169588 6531_ $$aBiomarker
000169588 6531_ $$aGlobal brain analysis
000169588 6531_ $$aPsychiatric  Disease
000169588 700__ $$0245162$$aSalomon, Roy$$g209116
000169588 700__ $$aBleich-Cohen, Maya
000169588 700__ $$aHahamy-Dubossarsky, Avital
000169588 700__ $$aDinstien, Ilan
000169588 700__ $$aWeizman, Ronit
000169588 700__ $$aPoyurovsky, Michael
000169588 700__ $$aKupchik, Marina
000169588 700__ $$aKotler, Moshe
000169588 700__ $$aHendler, Talma
000169588 700__ $$aMalach, Rafael
000169588 773__ $$j31$$k36$$q12972-12981$$tThe Journal of neuroscience : the official journal of the Society for Neuroscience
000169588 8564_ $$s3163896$$uhttps://infoscience.epfl.ch/record/169588/files/Salomon_2011_Global%20functional%20Connectivity%20deficits%20in%20Schizophrenia.pdf$$yn/a$$zn/a
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000169588 937__ $$aEPFL-ARTICLE-169588
000169588 973__ $$aOTHER$$rREVIEWED$$sPUBLISHED
000169588 980__ $$aARTICLE