000168577 001__ 168577
000168577 005__ 20190316235211.0
000168577 022__ $$a1471-213X
000168577 02470 $$2ISI$$a000294182400001
000168577 0247_ $$2doi$$a10.1186/1471-213X-11-47
000168577 037__ $$aARTICLE
000168577 245__ $$aAnalysis of the dynamics of limb transcriptomes during mouse development
000168577 269__ $$a2011
000168577 260__ $$bBioMed Central$$c2011
000168577 336__ $$aJournal Articles
000168577 520__ $$aABSTRACT: BACKGROUND: The development of vertebrate limbs has been a traditional system to study fundamental processes at work during ontogenesis, such as the establishment of spatial cellular coordinates, the effect of diffusible morphogenetic molecules or the translation between gene activity and morphogenesis. In addition, limbs are amongst the first targets of malformations in human and they display a huge realm of evolutionary variations within tetrapods, which make them a paradigm to study the regulatory genome. RESULTS: As a reference resource for future biochemical and genetic analyses, we used genome-wide tiling arrays to establish the transcriptomes of mouse limb buds at three different stages, during which major developmental events take place. We compare the three time-points and discuss some aspects of these datasets, for instance related to transcriptome dynamics or to the potential association between active genes and the distribution of intergenic transcriptional activity. CONCLUSIONS: These datasets provide a valuable resource, either for research projects involving gene expression and regulation in developing mouse limbs, or as examples of tissue-specific, genome-wide transcriptional activities.
000168577 6531_ $$aLong Noncoding Rnas
000168577 6531_ $$aVertebrate Limb
000168577 6531_ $$aGene-Expression
000168577 6531_ $$aGtl2 Gene
000168577 6531_ $$aChromatin
000168577 6531_ $$aEvolution
000168577 6531_ $$aGenome
000168577 6531_ $$aGrowth
000168577 6531_ $$aDifferentiation
000168577 6531_ $$aPluripotent
000168577 700__ $$aGyurján, Istvan
000168577 700__ $$0242848$$g178420$$aSonderegger, Bernhard
000168577 700__ $$0240296$$g110606$$aNaef, Felix
000168577 700__ $$0240276$$g141236$$aDuboule, Denis
000168577 773__ $$j11$$tBMC developmental biology$$q47
000168577 8564_ $$uhttp://www.ncbi.nlm.nih.gov/pubmed/21801425$$zURL
000168577 909C0 $$xU11260$$0252319$$pUPNAE
000168577 909C0 $$pUPDUB$$xU11705$$0252099
000168577 909CO $$qGLOBAL_SET$$pSV$$particle$$ooai:infoscience.tind.io:168577
000168577 917Z8 $$x182482
000168577 917Z8 $$x182289
000168577 937__ $$aEPFL-ARTICLE-168577
000168577 973__ $$rNON-REVIEWED$$sPUBLISHED$$aEPFL
000168577 980__ $$aARTICLE