Enantioselective total synthesis of cylindramide
Key steps in the convergent enantioselective synthesis of the cytotoxic natural product cylindramide are tandem Michael addn./electrophilic trapping reactions, Sonogashira coupling, Julia-Kocienski olefination, and macrocyclization. For example, the Sonogashira coupling of pentalene I with iodoacrylate II followed by Julia-Kocienski olefination with sulfone III gave an intermediate which underwent macrocyclization. Formation of the tetramic acid completed the synthesis.
Cite this item
Cramer, N., Laschat, S., Baro, A., Schwalbe, H., & Richter, C. (2005). Enantioselective total synthesis of cylindramide. Angewandte Chemie International Edition, 44, 820–822. https://doi.org/10.1002/anie.200461823
Click Copy to copy the citation, or select the text manually.
2005
44
820
822
CAPLUS AN 2005:104408(Journal)
REVIEWED
OTHER