Enantioselective C-C bond activation of allenyl cyclobutanes: access to cyclohexenones with quaternary stereogenic centers
2008
Abstract
Chiral rhodium(I) complexes activate allenyl tert-cyclobutanols efficiently through enantioselective insertion into a C-C σ bond of the cyclobutane. Ring expansion by this method produced cyclohexenones with quaternary stereogenic centers with excellent enantioselectivity. The catalyst loading can be decreased to just 0.1 mol% in rhodium.
Details
Title
Enantioselective C-C bond activation of allenyl cyclobutanes: access to cyclohexenones with quaternary stereogenic centers
Author(s)
Seiser, Tobias ; Cramer, Nicolai
Published in
Angewandte Chemie, International Edition
Volume
47
Pages
9294-9297
Date
2008
Publisher
Wiley-VCH Verlag GmbH & Co. KGaA
ISSN
1433-7851
Keywords
Note
CAPLUS AN 2008:1483761(Journal)
Laboratories
LCSA
Record Appears in
Scientific production and competences > SB - School of Basic Sciences > ISIC - Institute of Chemical Sciences and Engineering > LCSA - Laboratory of Asymmetric Catalysis and Synthesis
Peer-reviewed publications
Work outside EPFL
Journal Articles
Published
Peer-reviewed publications
Work outside EPFL
Journal Articles
Published
Record creation date
2011-08-17