Enantioselective C-C bond activation of allenyl cyclobutanes: access to cyclohexenones with quaternary stereogenic centers

Chiral rhodium(I) complexes activate allenyl tert-cyclobutanols efficiently through enantioselective insertion into a C-C σ bond of the cyclobutane. Ring expansion by this method produced cyclohexenones with quaternary stereogenic centers with excellent enantioselectivity. The catalyst loading can be decreased to just 0.1 mol% in rhodium.


Published in:
Angewandte Chemie, International Edition, 47, 9294-9297
Year:
2008
Publisher:
Wiley-VCH Verlag GmbH & Co. KGaA
ISSN:
1433-7851
Keywords:
Note:
CAPLUS AN 2008:1483761(Journal)
Laboratories:




 Record created 2011-08-17, last modified 2018-12-03


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