Enantioselective C-C bond activation of allenyl cyclobutanes: access to cyclohexenones with quaternary stereogenic centers
Chiral rhodium(I) complexes activate allenyl tert-cyclobutanols efficiently through enantioselective insertion into a C-C œÉ bond of the cyclobutane. Ring expansion by this method produced cyclohexenones with quaternary stereogenic centers with excellent enantioselectivity. The catalyst loading can be decreased to just 0.1 mol% in rhodium.
CAPLUS AN 2008:1483761(Journal)
Record created on 2011-08-17, modified on 2016-08-09