Synthesis and biological activity of largazole and derivatives
A modular synthesis of the marine natural product largazole and related synthetic analogs is described. Largazole was prepd. in 10% overall yield through a synthetic route with a longest linear sequence of nine steps. Activity tests showed the necessity of the thiobutenyl moiety for antiproliferative activity.
CAPLUS AN 2008:1047341(Journal)
Record created on 2011-08-17, modified on 2016-08-09