Synthesis and biological activity of largazole and derivatives

A modular synthesis of the marine natural product largazole and related synthetic analogs is described. Largazole was prepd. in 10% overall yield through a synthetic route with a longest linear sequence of nine steps. Activity tests showed the necessity of the thiobutenyl moiety for antiproliferative activity.


Published in:
Angewandte Chemie, International Edition, 47, 6483-6485
Year:
2008
Publisher:
Wiley-VCH Verlag GmbH & Co. KGaA
ISSN:
1433-7851
Keywords:
Note:
CAPLUS AN 2008:1047341(Journal)
Laboratories:




 Record created 2011-08-17, last modified 2018-03-17


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