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Enantioselective construction of indanones from cyclobutanols using a rhodium-catalyzed C-C/C-H/C-C bond activation process

Enantioselective rhodium(I)-catalyzed reactions of tert-cyclobutanols, e.g. I, lead to indanones with quaternary stereogenic centers, e.g. II, via consecutive C-C/C-H/C-C bond activations.

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