Enantioselective rhodium-catalyzed C-C bond activations

A review. The catalytic activation of C-C single bonds represents a major challenge in organometallic chem. Strained ring substrates occupy in this respect a privileged role as their inherent ring strain facilitates the desired metal insertion. Employing sym. substituted tert-cyclobutanols, an enantioselective Rh(ι)-catalyzed β-C elimination creates alkyl-Rh species bearing all-C quaternary stereogenic centers. Downstream reactions enable access to a wide range of synthetically versatile products such as substituted cyclohexenones, lactones and indanols with excellent enantioselectivities of up to 99% ee.


Published in:
Chimia, 64, 153-156
Year:
2010
Publisher:
Swiss Chemical Society
ISSN:
0009-4293
Keywords:
Note:
CAPLUS AN 2010:507839(Journal; General Review)
Laboratories:




 Record created 2011-08-17, last modified 2018-03-17


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