Enantioselective rhodium-catalyzed C-C bond activations
A review. The catalytic activation of C-C single bonds represents a major challenge in organometallic chem. Strained ring substrates occupy in this respect a privileged role as their inherent ring strain facilitates the desired metal insertion. Employing sym. substituted tert-cyclobutanols, an enantioselective Rh(Œπ)-catalyzed Œ≤-C elimination creates alkyl-Rh species bearing all-C quaternary stereogenic centers. Downstream reactions enable access to a wide range of synthetically versatile products such as substituted cyclohexenones, lactones and indanols with excellent enantioselectivities of up to 99% ee.
CAPLUS AN 2010:507839(Journal; General Review)
Record created on 2011-08-17, modified on 2016-08-09